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| User Info | There's An Off Ramp - But It Has A Price; entered at 2021-08-31 12:50:55 | |||
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Keenan Posts: 540 Registered: 2013-01-11 Western PA 
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Another OTC compound to be considered for your anti-Coof arsenal: A study published in the Proceedings of the National Academy of Science indicates that lactoferrin demonstrates potential for prophylaxis and treatment of SARS-Cov-2: snip: Here, we showed that lactoferrin likely has a multimodal mechanism of action against SARS-CoV-2 infection (Figs. 6 and 7). First, it strongly inhibited cellular binding of SARS-CoV-2 to cells via competition with heparan sulfate. Second, it modulated host cell innate immune responses through increased expression of interferon-stimulated genes and TNFα. Through heightening the innate immune response of host cells, orally administered lactoferrin could be effective in resolving the GI symptoms that are present in COVID-19 patients (41) with a mechanism similar to norovirus infection (42). In addition, lactoferrin was previously shown to decrease the production of IL-6 (43), which is one of the key players of the cytokine storm produced by SARS-CoV-2 infection (44, 45). Bovine lactoferrin, widely available as 250-mg gelatin capsules for oral administration, is classified by the FDA as generally recognized as safe and therefore may represent a promising therapy for preexposure and postexposure prophylaxis. As a therapeutic intervention for COVID-19, lactoferrin might exert direct antiviral and anti-inflammatory efficacy in the airway with alternative routes of administration like intranasal delivery or in a nebulized formulation delivered to the lungs. Full article: https://www.pnas.org/content/118/36/e210.... 2021-08-31 12:50:55
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