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2021-04-28 07:00 by Karl Denninger
in Covid-19 , 94337 references Ignore this thread
Science Catches Up -- And Burns You All*
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There is a reason science is a process and until you understand something you should keep your ******ned mouth shut.

Especially when all you have against 40+ years of hard science is computer models.

Massssskss was one of them.  I warned early on that physics said masks could not work if the virus was in aerosols or transmitted in feces, no matter whether the feces were manually spread or through aerosols.  We knew this was virtually certain when a mass-spread event happened twice in Wuhan and Hong Kong in apartments on the same vertical drain stack where there were no P-traps; the people infected did not know each other and thus any other form of transmission other than through fecal aerosol was wildly improbable.  That was ignored.  We then had the German meatpacking plant where everyone was wearing masks and yet a huge outbreak took place across tens of feet, a claimed impossibility.  Yet it happened and was proved by RNA sequencing; the researchers were able to identify the index and daughter cases and thus conclusively prove that the infections happened in that plant via that route, despite masks.

Now MIT has weighed in and said the same thing. They try to sidestep the mask issue in their "research" but fail; nothing less than an N95, which is not a mask but rather a respirator, stops aerosols, and source control does not work even with N95s because when you exhale the positive pressure escapes around the edges and for aerosols goes right through the gaps.  Workplaces and airlines have banned N95s with exhaust valves which preserve the seal on your face and thus are the only ones that will provide protection for you against inhaling said aerosol.  Non-valved respirators repeatedly break said seal and thus render it ineffective within minutes.  Don't believe me?  Put on an N95 without a valve and do some sanding where there's lots of dust, when you take it off let me know what you find around the edges where the respirator used to be.  This is why you want the ones with a valve and why the ones I have for such work have a valve.

Pay attention to this paper folks and note its publication date, January 2021.  Nobody has paid any attention to it at all yet it is peer-reviewed in Nature, one of the "better" medical publications.  I will start right here with what you do not want to read, but you damn well should before you take the shots.

This T cell-mediated immune response is even more important as studies on humoral immunity to SARS-CoV-1 provided evidence that antibody responses are short-lived and can even cause or aggravate virus-associated lung pathology

Note that when you get the shot the first thing you get is antibodies; you may get a T-cell reaction.  This pre-existing knowledge, from SARS (CoV-1) entirely explains why people who just got vaccinated often get hammered by the virus and frequently end up in the hospital or die.  It marks the premise of attempting to vaccinate out of a pandemic where transmission is actively occurring as stupid.

You go get the shot.  Five days later you get the virus.  You have not yet developed immunity and the partial expression makes it worse.

You would have been better off, by far, taking the same infection straight up front.  It likely would have harmed you less.

This generally applies, by the way, to all vaccines and all viruses.  The government and researchers know this.  They've known this for decades.  It's fact.  It's why you don't wait until the measles is raging around you to get a measles vaccine and the same is true for the flu shot; you get it before the flu season starts for this very reason.  Attempting to vaccinate out of a raging infection does not work and in fact kills people.

Yeah, if you don't get infected during that latent period you get protection.  But if you do get infected you're screwed and all of the two-dose shots have a roughly four week window during which you get hosed instead of protected.  Israel's data, by the way, proves this is real; Berenson has been reporting on it since the beginning of the year and I've noted it as well.

If you remember I've also pointed out that multiple studies have shown that somewhere between 30-50% of the population is T-cell reactive to Covid-19 despite never having had it, nor SARS or MERS, its alleged "precursors."  But those studies were non-specific; that is, they looked for T-cell reactivity but never tried to identify the specific protein sequences and their part of the whole that was involved.  This study does, and it finally puts light on basically the entire reason that what we've done is not only wrong it's criminally stupid.

These folks did what we should have done originally -- they isolated a panel of 120 peptides that comprised roughly 10% of the entire virus, containing 57% and 1% of the nucleocapsid and spike proteins.  Note that while the "spike" facilitates entry into the cell there is evidence that it is, standing alone, pathological -- that is, it causes disease in the human body without the rest of the virus.  The nucleocapsid portion, on the other hand, is the part that is responsible for replication; if it is tagged and the cell containing it is destroyed then viral replication is prevented even though penetration of the cell has occurred.

I draw your attention to this graph:

 

This fully explains the wild divergence in outcomes even among similarly-morbid people.  The more "matches" you have on a pre-existing basis the more-fully your immune system can recognize the virus and while you will get infected if those matches are among the nucleocapsid section you're much more-likely to drive it off without serious consequence.

Note that among the "PRE" (not-infected) collection of samples all were prior to November of 2019 and thus presumed non-infected.  We in fact know there were infections during that time frame but most in that group were from wildly before Covid-19 by as much as 10 years or more, so the cross-contamination percentage is going to be very low.

Now let me point to the data itself.

Of the SARS donors, 100% showed T cell responses to cross-reactive and/or specific ECs (HLA class I 86%, HLA-DR 100%; Fig. 5d,e), whereas 81% of PRE donors showed HLA class I (16%) and/or HLA-DR (77%) T cell responses to cross-reactive ECs (Fig. 5d).

81% eh?  Isn't that an interesting number?  Where have we seen that before?

You know damn well where, don't you?

It's the rough percentage of alleged Covid-19 infections that were either asymptomatic or very low-symptom for which no medical treatment was sought and, in many cases, not detected.

So it wasn't 30 or 50% who had pre-existing protection it's actually roughly 8 in 10!  This was not a "novel, everyone is susceptible" virus at all.  It never was.  You were lied to from the very beginning and thus all the "models" based on that were trash.

Again, just a bit further down:

Taken together, SARS-CoV-2 T cell epitopes enabled detection of post-infectious T cell immunity in 100% of individuals convalescing from COVID-19 and revealed pre-existing T cell responses in 81% of unexposed individuals.

Now we know why Diamond Princess happened the way it did.  It was never possible for more than 20% of the people on that ship to get seriously-symptomatic Covid-19 despite being cooped up in close quarters for weeks with an aerosol-spread disease and cruise passengers generally being wildly-overrepresented for various morbidity factors.  It also completely explains why one of two people quarantined in the same cabin got sick and the other did not.

We also know why my friend's grandfather was killed by it but his equally-morbid grandmother was not touched symptomatically even though she tested positive despite literally sleeping in the same bed with him until he wound up in the hospital and ultimately expired.

We also know why there is no place on the planet that has seen >20% of people with significant, symptomatic disease from Covid-19.  Not a single place has had that happen, even where sanitation is crap and people spread it like crazy (e.g. Iran where they lick monuments sequentially -- literally.)

This study explains every single example seen everywhere in the world, including high-concentration examples, of infection with Covid-19 back to the start of the pandemic.  We now know why no more than 20% of any exposed population has ever exhibited materially-serious disease -- it simply was not possible as no more than 20% of the population was potentially susceptible to serious disease.  Ever.  Period.

EVERY SINGLE STATEMENT OTHERWISE WAS FALSE AND EXACTLY ZERO SO-CALLED "PUBLIC HEALTH" AUTHORITIES OR POLITICANS HAVE EVER ADMITTED TO THIS, YET IT IS NOW SCIENTIFICALLY PROVED THEY WERE COMPLETELY FULL OF CRAP FROM THE FIRST DAY ONWARD AND WE KNEW SO, BUT NOT WHY, AFTER DIAMOND PRINCESS AS I HAVE REPEATEDLY POINTED OUT.

NOW WE KNOW WHY -- WITH SCIENTIFIC CERTAINTY.

Let me distill this down for you before I go on:

In 100% of the persons who had and recovered from Covid-19 and 81% of those who have never had the virus a vaccine may well be worthless as they already have T-cell response.  While this will not prevent them from getting it again there is questionable at best benefit over their existing immunological state but there is risk, including a risk of death, from the side effects.

Furthermore, evidence was provided for a lower recognition frequency of cross-reactive HLA-DR EC in hospitalized patients compared to donors with mild COVID-19 course, which might suggest a lack of pre-existing SARS-CoV-2 T cells in severely ill patients.

No kidding?  Gee, yet more points of contact with the obvious?

Then there's this:

Our observation that intensity of T cell responses and recognition rate of T cell epitopes was significantly higher in convalescent patients compared to unexposed individuals suggests that not only expansion, but also a spread of SARS-CoV-2 T cell response diversity occurs upon active infection.

Let me be clear: The entire premise of all of the "mitigations" and demand for mass-vaccination relied on a lie; that this was a "novel" virus to which nobody had existing resistance.  We now know that's false; 81% of the population in fact does have existing immunity and further, that immunity is strengthened, materially so, by natural infection.  In short if you have said partial resistance you want to get the disease as the odds of you being seriously harmed are statistically zero yet you will perfect your immunity and from a public health perspective you want those people who are not going to be seriously harmed to get it naturally, not take a ******ned shot because it is that perfection of immunity that stops the disease from being of harm to the public on a durable basis.

It gets worse -- the resistance isn't to the spike, it's almost-exclusively to the nucleocapsid portion of the virus among those with existing resistance; the largest set of reactions by far was to the nucleocapsid, not the spike.  This is very strong evidence that it is that nucleocapsid reactivity that provides effective resistance to serious disease.  The existing "vaccines" do not and cannot provide this since they encode only the spike.

Again for those who are reading-comprehension challenged: The existing vaccines are worthless for building said perfected immunity since the data is that the nucleocapsid section, which the vaccines do not code, is where most of the pre-existing resistance against serious disease resides.

 

Who is in the "not at risk" group?  Basically everyone under 50; said persons have comprised less than 5% of the deaths and especially those under 18 who almost never get serious ill or die.  This means we should have never closed schools, never masked kids and in fact we should have encouraged the equivalent of mass chicken-pox parties for both children and healthy young adults, especially in colleges.  The current push to vaccinate college students is not only stupid it's directly counter-productive to them building a robust and durable, likely life-long, immune response to this specific virus including the variants.

The colleges doing this and all of those advocating or demanding same, including VUMC, the entire Cal system and more should immediately have every single person involved indicted, imprisoned and their entire familial tree erased from the human record.  What they are doing is directly harmful to public health and is very likely to cause death.

Further this paper points out that induction of immunity against the spike may well be worthless or even harmful.  Again "prevention of infection" is meaningless if it is bypassed and you get hammered, as has repeatedly occurred during the window following vaccination.  Indeed, such might even enhance the progress of infection and mortality and if that's not enough insult there's reason to believe the same enhanced risk may also present itself on the "back end" as antibodies to the spike wane too with no way to know when that window occurs in a specific individual.

It is quite clear from this study that recognition of the nucleocapsid proteins is the difference between asymptomatic or mild infections and severe ones; the correlation is exact and yet exactly zero of the existing vaccines target anything other than the spike.  You cannot build immunity to that which is not presented.  With the spike now having evidence of direct pathology and in fact quite possibly being why serious organ damage and death occur with natural infection we have clearly gone down the wrong road with "warp speed" and in fact may have done irrevocable and severe harm to millions of Americans while failing to induce long-term nucleocapsid immune recognition which occurs via natural infection and is the key to turning a potential infection into a nuisance at worst.

Short-term prevention of "infection" among the 81% of those with existing T-cell recognition to the nucleocapsid proteins is not only stupid it is likely to kill people over the intermediate and longer term since those who are not vaccinated and get infected with partial resistance build additional and durable immunity via said low-symptom and asymptomatic infections which do not materially harm them and blocking that process is harmful, not helpful.

This group includes nearly all young adults and children for which people are trying to force vaccination.

There are some holes in this study that require more work; specifically, trying to pin down how much protection is afforded by which specific nucleocapsid recognition profile, and how cytokine production bears on that along with binding properties.  This is definitely not the last word on such by any means, but it is a rather important contribution -- and one we should have pursued given that it certainly appears to fully explain the low-symptom and asymptomatic "infections."  The authors note this and intend to do further study.  Good!

What is not clear yet is where the cross-reactivity came from; it's obviously some other disease and it didn't kill the person with it; perhaps intentional infection with something that causes nothing more than a cold would be a good idea eh?  Of course first we must identify what gave that 80% of the population their cross-reactivity, which we have not done -- again, on purpose, despite having a full year to work on it.

To repeat this study is 100% congruent with what we have seen thus far in the wild with this virus.

EVERY LAST BIT OF IT.

Oh, and that's not the only evidence that the spike protein alone is pathogenic.  There's this study too, which if it proves up means every one of the existing vaccines in the western world is directly dangerous.

One point stands out from this study and, in combination with the study documenting pathogenic response to the spike protein alone is now evident: "Warp Speed" was stupid; it targeted the wrong thing, it has made people specifically vulnerable to nasty outcomes during the month or so before "protection" is allegedly achieved and fails to provide durable protection to the nucleocapsid portion of the virus as it does not target that at all.  Further, in roughly 80% of the population as a whole taking the shot is worse than worthless since they are not exposed to severe disease in the first place but the shot is likely to temporarily block the asymptomatic or low-symptom infection that would perfect their natural immunity to the nucleocapsid portion of the virus that is required for replication while exposing said persons to the risk of severe or even fatal side effects by producing a systemic invasion of the spike protein which, if said person was naturally infected, would likely not occur since the person's immune system can recognize the original infected cells in the respiratory tract and prevent the replication cycle from completing and becoming systemic.  And even worse at some point in the future as antibodies wane said persons without nucleocapsid protection are exposed to that risk again but have no idea when that risk has become significant since there's no reasonable way to know what your antibody titer is over time.

Do you think the Chinese knew all of this up front given that their vaccines are all full-protein inactivated and thus include the nucleocapsid portion?  If they deliberately gave us a sequence they knew was directly and singularly pathogenic while ignoring the required nucleocapsid protection for durable protection then Beijing and the CCP must be immediately nuked to ash as they deliberately attempted to kill people worldwide and every single pharma company, US Government agency, "public health" organ and individual who cheered this on and went along with it unquestioned must be completely and irrevocably destroyed.

I note that we do not even know if the nucleocapsid portion of the virus, inactivated, is pathogenic.  It very well might not be and had we produced inactivated vaccines via that route without the spike protein being present they would likely have a similar risk profile to the seasonal flu shot instead of being 100 or more times as dangerous and at the same time they would have provided durable protection that all of the current shots do not because they omit said nucleocapsid sequences on purpose.

WE ****ED OFF FOR AN ENTIRE YEAR INSTEAD OF INVESTIGATING THIS AND EVERY SINGLE ENTITY INVOVLED DESERVES TO BE HELD TO ACCOUNT FOR EVERY SINGLE DEATH THAT RESULTED FROM THAT DELAY PLUS ALL THOSE THAT RESULT FROM THE CURRENT CROP OF "VACCINES" OVER THE NEXT SEVERAL YEARS IF THIS PROVES UP -- AND I BET THERE IS A HIGH PROBABILITY IT WILL GIVEN WHAT WE'VE ALREADY SEEN IN ISRAEL AND ELSEWHERE.

It was criminally stupid to suppress and block drugs we knew were safe and might work in furtherance of this insanity.

Instead of what we're doing we should have -- and must, right now and today -- immediately hand out Ivermectin and Budesonide (inhaled) to anyone who appears to be sick with Covid-19, scrap all of the existing alleged "vaccines" pending study of the nucleocapsid portion of the virus and look to see if an inactivated poly-nucleocapsid cocktail is pathogenic.  If it is not then for those who want said shot and will benefit from it without blocking natural infections that perfect immunity in the population as a wholewhich include only those older and morbid, we should develop and offer that instead of what we're doing now through regular process, relying on prophylaxis and early treatment in the interim.  Yes, it will take several years to do so but that's the only correct path to take given the scientific evidence and we must do it now.

If the various state Departments of Health will not immediately start handing out said drugs when there is no prescription required to get an experimental shot then they should be disbanded with every single employee of same binned and shunned along with every so-called "public health" organ such as VUMC closed and bulldozed to bare earth.

EVERY ONE OF THEM IS NOW PROVED TO HAVE ALL BEEN WRONG ABOUT UNIVERSAL SUSCEPTIBILITY SINCE THIS BEGAN AND I ARGUE THEY IN FACT KILLED HUNDREDS OF THOUSANDS OF AMERICANS IN PURSUIT OF A WORTHLESS OR EVEN HARMFUL ENDPOINT BECAUSE THEY WENT DOWN THE WRONG PATH.

What we are doing now is encouraging more-contagious mutation and if we don't cut it out we may well pull the black ball and get the more-virulent mutation as well that will evade all those who are vaccinated and hammer the hell out of them since none got any nucleocapsid T-cell recognition from the shot!  If that happens those without said existing recognition are very likely to diewe could easily wind up killing 20% of those vaccinated because we were stupid.  Even if we do not pull the black ball said persons are at risk of the same thing happening as their antibody titers wane without any good way to know when.  Since response is individual there is no reasonable way to guess for any specific person nor is there any good way to know whether said person has existing nucleocapsid T-cell recognition (in which case they're reasonably-well protected and likely will remain so -- but in that case they never got anything useful out of the shot in the first place!)

THIS MUST STOP NOW.

I am not anti-vaccination; to the contrary, vaccines are one of a handful of clear medical triumphs.  I am anti-stupid, and producing, promoting and injecting people with something you do not yet understand the pathology of, taking your information from a potentially-hostile nation and not performing scientific verification first is stupid.

To continue said activity in the face of science documenting that you did it wrong goes beyond the realm of stupid and into the realm of criminal culpability for which no immunity should be recognized by anyone, ever, period.

And for the Love of God stop masking and restricting young and healthy people; the future of the world in terms of public health in fact requires that they be allowed to develop said natural, perfected immunity.  Preventing that by giving them a shot is felonious and anyone involved in it should be indicted, prosecuted and lose their life as the mass-murderers they will prove to be.

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