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2024-04-16 07:00 by Karl Denninger
in Covid-19 , 437 references
[Comments enabled]  
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That, bluntly, in other than very high risk people its worthless (but of course expensive):

Among the 1288 participants who received at least one dose of nirmatrelvir–ritonavir or placebo and had at least one postbaseline visit, the median time to sustained alleviation of all targeted Covid-19 signs or symptoms through day 28 was 12 days in the nirmatrelvir–ritonavir group and 13 days in the placebo group, a difference that was not significant (P=0.60) (Table 2). Similar results were observed in the high-risk subgroup (i.e., participants who had been vaccinated and had at least one risk factor for severe illness) and in the standard-risk subgroup (i.e., those who had no risk factors for severe illness and had never been vaccinated or had not been vaccinated within the previous 12 months).

It had zero impact statistically on the time to alleviation of symptoms.  The drug was bought and did not work.

However:

In a planned subgroup analysis involving high-risk participants, hospitalization or death occurred in 3 (0.9%) in the nirmaltrelvir–ritonavir group and 7 (2.2%) in the placebo group (difference, −1.3 percentage points; 95% CI, −3.3 to 0.7).

Problem: There was only one death in total so the difference here begs the obvious question on matching of morbidities and such in the trial arms.  How well was that done, given that they did find among the high-risk people a difference in hospitalization and ICU admittance?  It is not logical for these results to occur when the improvement time did not vary between the high risk and not-high-risk groups.

However, it is what it is.

But the real punchline is this:

From August 25, 2021, to July 25, 2022, a total of 1296 participants underwent randomization and were included in the full analysis population (Figure 1), and 1288 received at least one dose of nirmatrelvir–ritonavir (654 participants) or placebo (634 participants) and had at least one postbaseline visit. 

In other words before full approval by roughly a year the study outcome was known but hidden and not published.  As you probably recall you've seen "If Covid, Paxlovid" commercials yet the study says it won't help you get better faster.  Of course the government was paying for it and had been since late 2021 but again, within just a few months it was known that it didn't work and yet this was concealed.

In fact the FDA had no evidence when they made this statement:

“Today’s authorization introduces the first treatment for COVID-19 that is in the form of a pill that is taken orally — a major step forward in the fight against this global pandemic,” said Patrizia Cavazzoni, M.D., director of the FDA’s Center for Drug Evaluation and Research. “This authorization provides a new tool to combat COVID-19 at a crucial time in the pandemic as new variants emerge and promises to make antiviral treatment more accessible to patients who are at high risk for progression to severe COVID-19.” 

And yet just a few months later the company had in its hands evidence that there was no statistical improvement in recovery time between using it and not, yet that study was not published, the FDA was (apparently) not notified and no statement correcting the record was made by anyone.

Now here we are in 2024 and the data comes out -- after being hidden for nearly two years.

This is the world we live in folks -- plenty of money to be made and yet what you're sold doesn't have to work and nobody has a duty to tell anyone as soon as they know, via a formal study, that it doesn't. In fact the FDA went on to give full approval nearly one year after these study results were known.

Should we expect anything different given what we know happened with Remdesivir where the government continued to pay for it and hospitals continued to push it on patients even after a huge multinational study was completed and published showing it was worthless -- and using it came with the significant risk of destroying your kidney function.

I guess not.

Oh by the way, marketing something as effective when you know that it is statistically worthless is fraud.  It is like selling "brake pads" that you know do not stop a car.  If the law meant anything the entirety of the firm's Board of Directors and all their officers would be under indictment since the money stolen from both the government and patients is in the billions.

PS: Have you noticed anything interesting?  When did "new variants" stop showing up and getting all manner of press?

WHEN PEOPLE STOPPED TAKING MORE SHOTS.

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2022-11-01 07:00 by Karl Denninger
in Covid-19 , 4219 references
[Comments enabled]  
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Oh no you don't, bitch.

These precautions were totally misguided. In April 2020, no one got the coronavirus from passing someone else hiking. Outdoor transmission was vanishingly rare. Our cloth masks made out of old bandanas wouldn’t have done anything, anyway. But the thing is: We didn’t know.

Oh, but you claimed to know.  You didn't claim opinion and neither did anyone else on your side.  Like, for example, the claim that people should celebrate those who refused the jabs and then died.

Well how about those who took the jabs and then got screwed, either by side effects or worse, the new data that shows that within 60 days you're more-likely to wind up in the hospital or dead if you were jabbed than not?

Further, this is not a matter of luck, as Emily suggests and Clott Adams has claimed in his puerile attempt to evade responsibility for leading people to their doom.  Do stupid things, win stupid prizes may well apply to him from what I've heard reported of late (he long ago blocked me on social media for calling him out on jabby advocacy.)

Luck was not a factor on many people's parts, mine included.  Many of our positions were in fact the outcome of deductive reasoning, having put in hundreds of hours reading literal hundreds of scientific and medical papers that stretched back decades.  I gave up a hell of a lot of sleep over those two years attempting to analyze what was in front of me and provide useful commentary to the public going all the way back to Diamond Princess.

For example I concluded very early on that masks would be pointless.  Was this "speculation" or "luck"?  No; it was scientific fact that had been repeatedly confirmed over more than forty years, dating back to a study by Neil Orr published in 1981.  That study provided conclusive evidence that in a sterile field (an operating room) with every person present being a trained medical professional adherence to the use of medical-grade masks to interdict transmission of disease failed and in fact potentiated disease transmission.

Obviously nobody in the general public will do better than trained medical professionals and you cannot do better in terms of environment than a sterile operating room.  It was therefore impossible for masks to work -- this was known forty years ago.

How about ventilators?  We knew they were worthless in March of 2020 because in more than 9 out of 10 people with Covid they were used on in Wuhan the person died.  That was published very early and thus it was known they were valueless.  Yet everyone screamed for more things that killed people.  Here is the data table on that from the time -- March of 2020.

 

32 people were intubated and one survived.  Three got ECMO and that didn't work either; zero of those attempts were successful.

Ventilators and ECMO, in Covid patients, are worthless and this was known in March of 2020.  Yet CMS to this day pays hospitals a bonus if they intubate Covid patients despite knowing all the way back to March of 2020 that it was pointless and if it did anything at all it actually killed them.

We also knew in March of 2020 that if your kidneys got hosed you were screwed too; that is also in that table in that renal replacement did not save one patient (since there were 10, that means its less than 10% effective and perhaps zero.)

Yet CMS did and still does pay hospitals to stuff you full of Remdesivir which has a known side effect profile that includes destroying your kidneys as this risk was known when it was tried against Ebola years earlier and more people died when given the drug than if they got nothing.

We will never know how many people who went into the hospital and were given that drug were killed by the virus and how many were killed by the drug.  If the deceased was given Remdesivir and developed kidney failure it is a reasonable presumption the hospital killed them, not the virus.  Disentangling that is impossible; isn't that convenient when you pay the hospitals to give people a known-dangerous drug rather than paying said bonus only if the person walks out alive under their own power?  I don't need to prove who got killed by one or the other; I need merely to observe that anything you pay for you will get more of -- every time.  This is basic human nature so why didn't we pay bonuses to hospitals only for success?

My position on these things did not come from wild speculation -- it came from detailed and documented study which I dutifully linked in my commentary on a daily basis, expecting nobody to take my opinion at face value without the sources to back up my point of view.  Yet that position earned me the ire of many, including that of Google, Twitter and others who sought to force me to shut up about that which had been true forty years prior and still was at the time -- and remains so today.

Where is the apology and restitution to those of us who got this right not by random chance but by deductive reasoning that came from detailed and laborious study?  What about those who got sick, went to the hospital, were stuffed full of Remdesivir, suffered kidney failure and are now dead, including one of my friends?

At the root of Emily's sin is that she had no evidence for benefit in any of what she backed or the fear she instilled in her family and others, including her demands for policy but the harms of going down the road she advocated for were known.  Specifically, closing schools was known to be harmful in every case, with the only dispute over the degree of harm.  Masking children, especially young children, was known harmful too, because language development in children is largely through facial expression.  This isn't speculation; it has been known to be scientifically true for decades.  Thus we had on the one side known and serious harms and on the other no evidence whatsoever, just fear-driven belief.

This was and remains no different than someone who believes in "witchcraft" and then uses that belief as an argument for burning the alleged witch at the stake.  That harm will take place if you burn the witch is obvious but you have no evidence that the "spells", even if they were actually cast, did or would do anything at all.

Then there's the 40-odd years of economic and social study on pandemics spanning multiple academic works which made clear the correct action when it came to mitigations was to do nothing.  That is, you couldn't stop the virus so there was no benefit to mitigating factors but there was harm that each of those factors would, with certainty, cause.  Therefore from an analytical point of view the best and only defensible measure was to maintain normalcy through the economy and social environment to the maximum possible extent.

Personal fear does not trump 40 years of academic study, but for Emily it not only did so it drove her public pronouncements.  Hiding under the bed is a personal decision.  Demanding others do so, particularly when you start waving around credentials, is another matter.

Emily demanded, and got, the exact opposite of what decades of formal study concluded should be done differing only in degree from one place to another and we deliberately undertook courses of treatment despite having plenty of evidence they were worthless or even were responsible, in whole or part, for the death of the person in question.

Emily wishes for absolution after engaging in this enterprise and being a proponent of it.

Not only should she not get it she, her family and her employer should be utterly destroyed for not only pushing it on others but now trying to profit from it in "teaching" about it, when every bit of what was done in that regard was either due to laziness, fear-mongering, possible political animus (e.g. Trump) or all of the above.  In other words at best it displayed idiocy and at worst malice and nobody who claims the title of "Professor" should be allowed to use the excuse of idiocy.

You don't give someone who is malicious and unrepentant ""amnesty" in a just, lawful society -- you give them a trial and, upon conviction, a date with the hangman.

Unfortunately what Emily wanted didn't end with the stupidity surrounding masks.

Oh no, Emily was and is a shill for this too:

Another example: When the vaccines came out, we lacked definitive data on the relative efficacies of the Johnson & Johnson shot versus the mRNA options from Pfizer and Moderna. The mRNA vaccines have won out. But at the time, many people in public health were either neutral or expressed a J&J preference. This misstep wasn’t nefarious. It was the result of uncertainty.

Oh, that's all it was Emily?  It would appear you're lying by omission:

 

The Internet is forever; unless this particular excerpt as was posted on Twitter is forged you personally advocated for and supported the deprivation of human rights on the basis of your fear, without evidence, and you were wrong.  For that, above all else, you deserve punishment BEFORE due process exactly as you demanded happen to others.

You weren't alone; here's just one of hundreds of examples calling for people to be shot if they refused the jabs.  I saw more demands of that sort over 2021 than I can count.  You were one of those people varying only in degree so if you think you're getting away with running that crap as it if never happened you've got another think coming.

We further now know your pipe dream was pure horseshit, was predicated on lies and has produced real harm.  Let's go down the list.

Fact: There is no evidence that any vector-based medication, whether viral-vector (e.g. J&J) or mRNA (Pfizer/Moderna/etc.) is safe.  Neither has ever been used on a widespread basis, despite more than a decade of trying.  All previous attempts ended in failure either on efficacy, safety or both.  This is simply due to the mechanism by which they function; rather than introduce an antagonist to the body directly as with every other vaccine they reprogram the cellular machinery in cells that take up the material to produce the antagonist.  This in turn means the immune system will consider those cells which are reprogrammed but are part of the person to be a foreign invader and attack them.  Any injected medication will inevitably result in some of the material winding up in the circulation and thus some of the cells that will take that up are in the circulatory system and the immune system will attack them.  This will in every case result in some amount of damage to the person injected.  That's not speculation, it is fact, it is basic physiology and it cannot be evaded as the very design of the technology uses this exact mechanism to work; the only question to be answered is how bad the damage will be and how that balances against any benefit you might receive.  If you wish to falsify this fact with the claim of "new discovery" it will take decades of formal study to do so.  Until that is demonstrated there is absolutely no place in the medical world for these forms of therapy on a mass-administration basis.  Period.

Fact: There has never been a successful coronavirus vaccine developed and we now know that's true for these jabs too.  This is not due to not trying; we have tried for decades in both man and beast.  All previous trails have failed at the animal testing stage due to adverse events, whether by direct adverse events or causing ADE, potentiation of the actual infection.  The reason for the latter is partly due to the rapid mutational pattern that all coronaviruses exhibit.  We knew immediately, before the shots were deployed, that Covid also mutated rapidly and thus was extremely likely to exhibit evasion or enhancement whether immediately or down the road.  To deploy shots without conclusive proof that this decades-long unbroken record of failure in fact had changed was so wildly-irresponsible that anyone promoting it deserves prosecution and, upon conviction, the death penalty for depraved indifference to the very real possibility of mass-slaughter and morbidity either by disease propagation or direct injury.  It is not possible to obtain this evidence in three months time, say much less two or three years, and thus there was no ethical, moral or legal path to use these shots on a mass-basis given the known state of science at the time.

Fact: A vaccine must produce sterile immunity or it is not a vaccine.  You can take a prophylaxis against a disease but there is never a "public health" argument for a compulsion to do something that impacts nobody but you.  Changing the definition of "vaccine" post-hoc does not change facts but it does prove intent to maliciously deceive.  The original trials were never designed to demonstrate sterile immunity and this was public knowledge as the trial design was published at or around their initiation in the summer of 2020.  Deborah Birx has admitted that she knew this before the first shot went into the first arm.  Anyone "ordinarily skilled" in public health matters or epidemiology knew this too, as did anyone who read the study designs, such as myself.  To represent otherwise was to spread deliberate false information and Fauci, Joe Biden, Birx and thousands of so-called "medical professionals" did exactly that.  Emily says we should take steps to deal with those who spread deliberately false information.  When are the trials scheduled for Biden, Birx, Fauci, the VUNT who came after me here locally in public, every single Governor (including DeSantis, by the way) who pushed and still does push this crap, all the CEOs and more?  Yes, that list includes Trump.

Fact: There is now in those nations where we have the data publicly available and they used these technologies a wildly statistically significant and persistent increase in all-cause mortality that is not, in any plausible way, Covid related and what's much worse is that it is not falling back off to national baselines.  We've all seen the anecdotal reports of people dying of the "suddenlies" and "unexpectedlies" in age groups that statistically do not have that happen, such as cheerleaders, soccer players and the like.  The data shows that this pattern began to emerge a few months after the jabbing started and despite the poor uptake of boosters it has not gone away, implying that the damage done was permanent and these outcomes will be with us for a decade or more if we stop giving these shots now.  In other words the potential risks outlined above now appear to be realized risks.

Fact: We knew, because there were papers published as early as December of 2020, that the risk of severe or even fatal damage if the spike entered the circulation was not theoretical.  To deliberately continue on a program to inject people in a way that was physiologically certain to cause that to happen to some degree in each person is the definition of depraved indifference and that is the difference in law between negligence and murder.   No less than the Salk Institute flagged this discovery in December of 2020, following up a study from September that had suggested it might be true, and said paper was peer-reviewed and published by spring of 2021, long before most people had been jabbed and before all mandates.  That was more than sufficient evidence to put a full and immediate stop to the jabbing program and it was deliberately ignored.  Now we have a new study out of Europe that appears to show that one hundred percent of the people inoculated with these jabs suffer some degree of cardiac injury.  The medical and government personnel involved in this, never mind the corporate and educational actors must be held criminally accountable for these actions as they went ahead with approval and even mandates while intentionally ignoring evidence published by a highly-credible international medical society before mass-distribution began.

Moving on is crucial now, because the pandemic created many problems that we still need to solve.

FUCK NO.

"Moving on" requires the three steps that are always required to demonstrate penitence, none of which you or any of the other people involved in this garbage have displayed

Specifically:

  • You must admit you were wrong in all material respects where you were.   This extends to masks, schools and shots.  You must do so equally publicly to what you advocated and beg forgiveness for your wrong acts, advocacy and the harm that came from that which was imposed on others not by their free choice but rather by coercion or force, forfeiting every privilege and penny you gained therefrom.

  • You must make restitution for that imposition of coercion or force to the extent it is possible.  There are millions who were materially and even permanently harmed, including being killed as a result of this bullshit.  You can't make adequate restitution but you can forfeit everything you have including all credentials, all capacity to earn a living beyond the fast food industry and live out your miserable days bowing before every single person you meet in atonement.  You won't, of course, because you haven't even taken the first step -- that is, you still don't admit you did anything wrong and instead are making excuses for your behavior.

  • You must act to put into place legal protections such that what you did can NEVER happen again, and if it is attempted any person against whom it is attempted is fully within their rights to use whatever level of force is necessary to stop it, including lethal force.  Of course you'll never agree to that either, nor lift a single finger in furtherance of same, if for no other reason than you want to continue to force your view on others.  That, standing alone, makes you a monster.

Indeed the truth is you are nothing more than a smug piece of excrement unfit to draw oxygen from the air. 

In my opinion you are no longer afraid of a virus but you are very concerned that you may receive exactly the same amount of due process before you are punished by those you fucked, which by the way was none, that you advocated be imposed by force upon others.

I believe THAT, and only that, is why you penned your article and that same fear is why the editors at The Atlantic published it.

To both of you my answer is the same: FUCK OFF.

I will NOT grant amnesty, I will NOT forgive and I WILL rub your bullshit and record in your face at every opportunity, along with reserving the right and option to exact every lawful penalty I can against you and every institution you are associated with, now or in the future, for all eternity.

I remind you that the Biden Administration has yet to drop the "Emergency", it is still trying to mandate jabs and fighting said court cases even after they've lost and neither the Administration, NIH or CDC has issued one apology just as you have not.  Indeed the FDA and CDC have both recently acted to further protect the entities making and distributing these shots from any legal responsibility for the harm they may or have caused.

As a direct and sole result of your and others personal actions and choices I do not care if you and every single other person involved in this fiasco over the last two years receives zero due process before punishment is handed out, whether legally or otherwise, as neither you or they gave a wet crap about due process of law when you and they were acting to screw everyone else.  That which you refuse to accord to others you have no right to expect for yourself.  If that bothers you or keeps you up at night then perhaps you should have acted in accordance with said principles in the first place.

The only way we will stop this crap and prevent future incidents of this sort is if everyone who put their fingers in their ears and deliberately ignored known harms to demand a speculative benefit without a single shred of evidence, or worse ignored decades of evidence that the path they advocated for was dangerous and might have permanent, irreversible harms associated with it, such as these "viral vector" technologies and filling people full of wildly-dangerous experimental drugs in hospitals, is held to full account for their actions and the harms that their demands caused, not by personal choice of those who independently decided to do foolish things but who were coerced or forced, whether it was closure of schools, forced masking or mandates of any other sort including but certainly not limited to the jabs.

There is no money damage award that can provide restitution to the tens of millions of kids who have been irrevocably screwed out of two years of their educations, or those kids who were irrevocably screwed out of language development as the window has closed on that part of their developmental process.  Those harms are going to go through our economy and society for the next sixty to eighty years and there is nothing we can do to change that at this point.  You, and others like you, particularly Teacher's organizations and Democrat Governors, own every bit of that and deserve the consequences.

The ridiculous economic damage imposed through the wild spending spree and inflationary impact resulting from the numerous fiscal orgies vomited forth by both Trump and Biden in that regard is going to screw people for a generation into the future.  How do you propose to compensate the screwed for that harm?  You can't, but the harm is real.

Further, those who were lied to about these jabs or even worse, coerced cannot be made whole.  New study work out of Europe strongly suggests that every single person who got these shots suffered some degree of cardiac damage.  Some more, some less but if the data is correct every single person did take some amount of damageA separate French study found that nearly 3% of all persons injected with mRNA jabs had clinical (not simply elevated troponin) myocarditis damage and it was more common in women than men.  How do you compensate two hundred million Americans for what may well prove to be a decade or more off their life expectancy?  What about the kids who are now five or six and lose a parent ten years from now due to heart failure these jabs caused?  How about those who have already died due to this harm?  The number already screwed is in the hundreds of thousands in America alone and nobody knows if or when it will slow down or stop.

Never mind the CDC's "recommendation" to jab kids with this crap, which is entirely unsupportable on facts or science and thus has only one plausible explanation: It is the only way to get these jabs into the NCVIA liability framework and prevent Pfizer and Moderna from being sued to beyond the orbit of Mars with their "businesses" turned into a smoking hole as soon as the EUAs drop.

The difference between Emily's position and mine is that while I set forward my opinion and the data supporting it I did not attempt to force anyone to follow the same path or demand they come to the same conclusions.  If you came to a different conclusion and wanted to wear a mask I had no quarrel with that.  In fact I repeatedly pointed out that if you truly believed you needed respiratory protection the only sane thing to do was to go buy a P100, available at most home stores for painting and other fume-generating procedures which has an exhaust valve, replaceable cannisters for when their time-in-use expired and because it filters only in one direction it can actually provide a seal around both the nose and mouth.  I expected even that to fail, given what we knew early on about transmission, but if you concluded it would work then you were free to have at it.  If you, despite the lack of any long-term safety data and deliberately ignoring the fact that spike in the circulation was directly harmful wanted to jab yourself with said dangerous experimental drug anyway, judging that the potential benefits were work the risks, have at it as well.  I had no desire to nor did I advocate that anyone be forced to do or not do anything, but I did demand that those on the other side refrain from attempting to force compliance with their views and expectations which all were, in point of fact, predicated on fear rather than analysis and deliberately ignored the balance of harms in each and every case.

That was and is the difference between my position and those on the other side of the alleged "debate" and there is nothing any of us can do to change it now.

Amnesty for Emily and others like her?

Not a prayer in Hell, bitch.  Not now, not ever -- not for you or anyone else involved in any of this crap.

You're damn lucky the people of this nation have long ago lost their sack to whatever soy-infested crap they worship these days or everyone involved would have already been sacked -- justly so.

Try this sort of crap again -- ever -- and you might find the word "lawful" is left out of the description of what is justly earned and that suddenly said sack has been found.

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2021-09-24 05:03 by Karl Denninger
in Covid-19 , 13112 references
[Comments enabled]  
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... in a not-so-tiny nation called Spain, a nursing home had a nasty virus get into it.

It was March of 2020.  The nasty virus was called Covid-19.  And this nursing home, like so many others all over the world, was full of elderly, morbid people.  The mean age of residents was 85 and 48% were over 80 years old.  It was a killing field, like so many others.....

Within three months 100% of the residents had caught the virus.  Not presumed to have -- proved to have.

How do we know this?  Because almost every one of them seroconverted.  All but three out of 84 of them, to be precise.

Think about that last sentence for a second.

Almost every one of them seroconverted.

How's that possible?  Many of them died, right?  You can't seroconvert if you're dead.

No.  Not only did nearly none die none went to the hospital either because they rapidly figured out how to stop the virus from killing people -- and did exactly that.

You would have thought this would have been all over the news.  In point of fact not one mention of it was made.  Further, not one write-up was made in medical journals either until January of 2021, which I missed.  My bad -- out of the several hundred medical journal pieces, I missed this one.  It was brought to my attention on my forum and my jaw immediately hit the floor.

The jab train must continue, you see.  So must the ventilator train.  So must the money train, the mask train and the rest of the BS we have endured for the last 18+ months.

So must the slaughter for money, the fear, and the lies.

So what did these few nursing homes do that nobody has done since and nobody reported out at the time?

1. Early start of treatment, regardless of the severity of patient symptoms.
  - Antihistamines every 12 h: dexchlorpheniramine 2 mg, cetirizine 10 mg or loratadine 10 mg.

2. Patients with mild or recent-onset symptoms (cough, fever, general malaise, anosmia, polymyalgia):   
   - Azithromycin 500 mg orally every 24 h for 3 days if there is rapid improvement, and for 6 days if the duration of symptoms is prolonged.
   - If pain or fever, acetaminophen 650 mg/6–8 h.
   - Nasal washing and gargling with sodium bicarbonate water (half a glass of warm water with half a teaspoon of sodium bicarbonate).

3. If symptoms of severity (dyspnea, breathing difficulty, mild or moderate chest pain, with SpO2 <80%, heart rate >100 beats per minute at any time of the process):
   - Antihistamines + Azithromycin (see mild treatment management)
   - Levofloxacin 500 mg/12 h, up to 14 days of antibiotic treatment from diagnosis.
   - Mepifilin solution, 50 mg/8 h as a bronchodilator, until subjective improvement. Patients with previous lung disease (asthma or COPD) used their usual bronchodilators.
   - If the patient experienced increased breathing difficulty, prednisone 1 mg/kg/day divided into two doses until clinical improvement, and then it was slowly tapered down.
 
4. Prophylactic treatment for close contacts, including all asymptomatic residents:
  - Antihistamines at the same dose as symptomatic patients.

Ed 9/25 11:30 - Reformatted the cut section; it got mangled by the forum.  Still not what I'd like in terms of formatting, but at least it's readable now... and one typo corrected.

Look at that top line.

Cetrizine is otherwise known as Zyrtec.  Loratadine is otherwise known as Claritin.  Dexchlorpheniramine is not often-used in the US anymore, but it used to be.  The other two core drugs were Azithromycin and Levofloxacin, both common antibiotics with the first being the infamous "Zpak" from the HCQ+Zinc+Zpak combination that a fraudulent study was used to discredit.

Both of the first two antihistamines are available over the counter in most nations including the United States.  The dosing they used is twice that on the label.  The two antibiotics are both available anywhere for little money.

Before they started treating people three residents died.  The entire group of them had the common maladies of old age -- hypertension, diabetes, COPD, cardiovascular disease.  Most were using a huge range of existing drugs for their conditions (5 or more.)  

As soon as they started treating people the following happened:

All of our patients evolved satisfactorily and were recovered at the beginning of June. No adverse effects were recorded in any patient and no one required hospital admission. At the end of June, 100% of the residents and almost half of the workers had positive serology for COVID-19, most of them with past infection.

Not one adverse event occurred among these residents and staff and no hospitalizations were necessary either.

In pooled data 28% of the residents in similar nursing homes over the same time period died.  In these two, once they started treating with cheap drugs, leading with those available over the counter in the US, ZERO -- I repeat -- ZERO had a bad reaction to the protocol, ZERO died and ZERO were admitted to a hospital for treatment.

ZERO.

It was one hundred percent effective.

Yes, it's a small sample.  Go do the statistical math on the CI for that size sample and results if you insist.

According to the mechanisms of action described, these drugs would act synergistically in the early stages of the disease, which is why we consider it essential to start the treatment as soon as possible. Once the virus has colonized the respiratory system, the effectiveness is probably more limited, and hence the failure of these treatments in more advanced stages of the disease, when hospital admission is necessary. In our experience, early double antibiotics were effective to control the process in cases with moderate symptoms.

Nobody cared.

Nobody reported on this.

Nobody duplicated it either.

I didn't even realize this study existed; had I known of it guess what I would have added to my protocol when I got Covid-19 the first week of August of this year, since it happens to be in my medicine cabinet already for seasonal allergies?  Uh huh.  Two 60ct bottles of generic Claritin equivalent costs about $12 at WalMart.

Folks, think about this long and hard: In the worst-case scenario for those who this virus should have killed -- it killed nobody.  It should be killing statistically nobody today -- right here, right now.  How to prevent it from doing so was discovered in March and April of 2020 and intentionally ignored worldwide.

It is still being ignored today.

With these numbers there is no reason to fear a Covid-19 infection.  There is no reason to take a vaccine.  There was never a reason to develop a vaccine, especially the ones we have today; infection that does not produce severe disease is sterilizing and thus wildly superior to vaccinated immunity which is now proved to be failing worldwide.  There is no reason to wear a mask.

Every single one of these residents seroconverted and became immune with mild or moderate symptoms consistent with seasonal colds and flus and not one of them was put into the hospital or killed. The treatment is so goddamned cheap and available there's no excuse to not use it instantly on suspicion of infection and prophylactically among everyone else in your household at first sign of trouble.

You think the entire load of BS around HCQ and Ivermectin is bad?  This is a thousand times worse.

Those who died did not do so due to a "novel coronavirus"; we knew how to treat that infection successfully for pennies in March and April of 2020.  Yes, in the first month or two people died because we did not know.

Beyond April of 2020 people died because we let the medical system and governments murder them for profit and they're still doing it today.  We, the people, have allowed this.  We have failed and refused to rise up and hold accountable, personally, every single hospital, doctor, so-called "hero" nurse and every single politician across the globe.  They willfully and intentionally slaughtered millions on a global basis.

The answer to the problem -- to Covid-19 -- was known in March and April of 2020 and yet not published until January of this year, and even then not one single bit of media attention nor a single mention from Fauci, the CDC, the NIH or FDA has been made, all in the interest of Moderna and Pfizer's stock prices and the power-mad jackasses on an international basis -- at the cost of your loved ones' lives.

That wasn't an accident and it still isn't one.

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2021-08-21 07:00 by Karl Denninger
in Covid-19 , 3399 references
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Now the CDC wants everyone to line up for a third round of clot-shot lottery.

Note carefully: The Israel data says this will fail and kill lots of people.

Aran’s message for the United States and other wealthier nations considering boosters is stark: “Do not think that the boosters are the solution.”

That's right.  They're not.

Delta may be more-transmissible but if you're immune it does not matter how transmissible a virus is.  You either can or cannot be infected.  It's binary.  If you're immune then you're immune.  If you're not then you're not.  If you have had Chicken Pox (I have) you'd look at anyone telling you to take a chicken pox shot as if they had six heads because such a suggestion is flat-out batshit-crazy-level insanity.

The idea that somehow Delta "can" break through immunity because it is more transmissible is flat-out scientific fraud and everyone who says that and has any knowledge of viruses and immunity knows it.  They're lying, on purpose, and every one of them deserves to be locked up in GITMO as a fucking terrorist and waterboarded to within an inch of their lives.

The reason Delta is "breaking through" is either due to OAS or the fact that the vaccines never did work worth a crap in the first place to prevent you from getting infected.  Their "efficacy" was a lie but whether its due to mutational reality or the fact that we claimed "effectiveness" simply due to herd effects with the existing circulating strains at the time does not matter.

My suspicion is that there is a blend of both going on here and there is science to back that up; the mutational pattern that we have seen and the science behind it says that evasion is happening.  The "wild coding" used originally and to this day for the jabs is long-extinct; there is basically zero of that circulating anymore in the population.  It has all been subsumed by ordinary mutational process and we had every reason to believe this would happen when Covid-19 first showed up because it has happened with every other coronavirus we have studied through history -- including the closest analog SARS-1 which mutated itself out of transmission and being a threat to people.

This is much like what happens with the flu shot every year: They have to guess which specific flu strains and mutations will show up in advance.  They're never right.  Their match varies in effectiveness but is basically never 100%.  Get it (sort of) right, you get decent protection.  Get it wrong you get little or nothing.

Except: Every coronavirus in history has mutated at a high rate in the spike domain.  All of them.  We knew this and we ALSO knew before the first shot went into the first arm the strain against which the vaccines were developed -- all of them -- was extinct in the wild, having been out-competed by said mutations.

We lied about the effectiveness by taking advantage of a peak in infections for the circulating strains last winter that was already in the past.  It was a knowing, intentional lie used to get 150+ million Americans to do something with waning toward worthless effectiveness but with 100x higher risk than the ordinary flu shot or, for that matter, any other vaccine in history.

The match has continued to degrade; it is biologically impossible to win that "arms race" as the virus will continue to change, and attempting to jab people with repeat inoculations as the match gets worse and worse over time simply adds to the risk of serious adverse events including clotting, strokes and heart damage.   Note that despite knowing this there has been no change made to the formulations.  What are you going to do -- throw all the existing doses and pipeline for them in the trash every time a new mutation shows up?

What we did was fight a war that cannot be won by the means employed and any honest person knows it.  The entire fucking government and medical apparatus knew this, lied about it and continues to lie today.  All of them.

They KNOW they're full of shit.

Rather than accept this fact and focus our attention on determining the most-effective ways to interdict infections early in people with a goal of allowing the infection to course its way through the population while not killing the victims or sending them to the hospital we instead took an utterly insane approach that focused on the idea that we could prevent people from getting the virus at all.  Whether that was masks (worthless since the virus is a tiny fraction of the size of the filter media and goes right through it), lockdowns (pointless; all you do is delay the inevitable) and now vaccines we keep being beaten around the head and shoulders by the virus which follows the laws of physics and undergoes natural mutation whether we like it or not.

I believed I might have had Covid-19 in January of 2020, even though I tested negative for antibodies several months later.  As it turns out my later antibody testing (negative) was correct and not a defective test; whatever I had in January of 2020 it was not Covid-19.

But now having had Covid-19 (almost-certainly Delta too) and knowing damn well it was Covid-19, and surviving it, it is a clearly-distinct infection that I could not possibly mistake for anything else.  That I was infected with Covid-19 is known scientific fact as I was previously IgG negative as of a couple months ago but now, following recovery from said suspected infection, am IgG positive.

Having had the infection and now having found IgG antibodies by test I am now known robustly immune to any and all variants; the immunity built from natural infection is conserved across the various epitopes of the virus in all cases because the "N" portion of the virus, which has to remain more-or-less intact for it to be able to be a virus, forms the backbone and bulk of the immune response built following natural infection.

I am not afraid of Covid-19 at any level any longer.  I am the exact person you want to employ to work in a hospital or nursing home full of very high-risk persons for severe Covid-19 because I am sterile to the virus; I can neither get it or give it to anyone.  Of course we would have to negotiate terms; money is not, I suspect, among the ones hospitals and nursing homes would have trouble with.

This is not true for any of the vaccines, it was a critical error in what we did and it is why we are now seeing escape.  It is not breakthrough folks, it is escape due to mismatch between the coded antibodies and circulating virus and it will both continue and accelerate as the match inexorably continues to degrade between what circulates and the original "wild type" out of Wuhan, which is what's coded in ALL the jabs and which is long extinct.  What's worse is that if OAS or ADE really come out to play on top of it then if you have not been naturally infected and have been jabbed you are in for a world of shit if you get challenged by the virus in the wild.  Even very, very small enhancement percentages from ADE-style reactions can completely overwhelm any sort of treatment possibility at all.

We do not yet know if this is happening as we are deliberately not autopsying and investigating cases where someone was vaccinated, got infected anyway and then rapidly crashed going from being moderately ill to in an ICU or dead within 72 hours.  There are multiple reports of this happening already.  If this was someone who had a defective immune response then that's very unfortunate but it does happen.  We had damned well better prove that, however, and we're not going the pathology work to do so.  If it turns out that said person did in fact build a proper immune response then these cases are either OAS or ADE-enhanced disease and while this outcome is clearly not universal in those who got jabbed if it is happening even once in a while we had better figure it out right fucking now or there is going to be a pile of dead bodies this fall and winter and it will be the direct responsibility of those who advocated for and in fact are trying to, in many cases, FORCE mass-jabbing of the population that caused it.

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2021-08-02 07:00 by Karl Denninger
in Covid-19 , 43559 references
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I warned everyone.

Now even CNN is on it, although they (like SAGE) think we're smarter than nature -- and evolution.

They write that some variants that have emerged over the past few months "show a reduced susceptibility to vaccine-acquired immunity, though none appears to escape entirely."

But they caution that these variants emerged "before vaccination was widespread," and that "as vaccines become more widespread, the transmission advantage gained by a virus that can evade vaccine-acquired immunity will increase."

In a word: Duh.

I know I've been banging on this drum since Covid-19 started but it is no-less important today, especially in the context of holding people accountable for killing several hundred thousand Americans and the economic destruction they brought upon the nation.

To be sterilizing a vaccine must prevent infection.  Since you never get infected you never replicate the virus and thus do not shed it.  If you do not shed it the potential path of the viral life-cycle for that particular infection ends with you and thus you cannot pass on or cause a mutation. You are sterile against that disease; from the point of view of the virus you are a lifeless rock.  Among commonly-used sterilizing vaccines are MMR (measles, mumps and rubella), Varicella (chicken pox), OPV (oral polio) and others.  The only time that such a vaccine fails is when you do not build immunity (such as due to immune compromise.)  This is extremely rare and the protection from such vaccines tends to be either decades-long or lifetime.

A vaccine that is not sterilizing permits the virus to infect you and replicate and as a result you can infect others.  Technically it is not a vaccine at all (which by definition prevents infection); it is a prophylactic therapy.  Such a "vaccine" instead acts to reduce or eliminate symptomatic disease.  You don't know you're sick and you don't get sick.  You don't go to the hospital and you don't die.  Unfortunately since you don't know you're sick but are infected and the virus is both replicating in you and shedding you are more-likely to spread the infection to others.  All of the current Covid jabs are in this category and so is, for that matter IPV (injected polio vaccine -- the original Salk discovery.)

During the original vaccine trials in the summer and fall of 2020 they deliberately did not test any of the recipients for asymptomatic infections.  Only a person who developed a significant illness was tested.  This has continued post roll-out with the CDC specifying that a close contact of a known case who was vaccinated did not need to quarantine or be tested until and unless they became symptomatic.  They knew damn well, in other words, that the jabs were not sterilizing but did not want that data up for public debate because then those who have read history would be likely to make the connection to the present day and thus they did their level best to hide it.  That has now blown up in their face with it being conclusively known that jabbed people in fact not only get infected but spread the virus to others.

The problem with non-sterilizing vaccines is simply this: There is no safe means of mass-use of non-sterilizing vaccines so long as transmission within the community does or is likely to exist.

Ever.

There are no exceptions.

This was known to public health officials and virologists seventy years ago and is why the United States used both IPV (injected polio vaccine) and OPV (oral polio vaccine) in sequence for polio until the 1990s.  OPV produced sterilizing immunity but IPV did not.  OPV had a very small (but non-zero, about 1 in a million) risk of causing polio because it was a codon-deoptimized live virus which, on rare occasion, would mutate back to its virulent form in the human body.  So to mitigate that risk you got IPV first in the US (to prevent systemic infection; this was non-sterilizing), then OPV which is sterilizing -- that is, it prevents not only getting sick from polio but also replicating and shedding the virus, thus giving it to others along with preventing the promotion of mutations that WILL eventually escape the vaccine.

Had we done with polio what we're doing now with Covid -- IPV (non-sterilizing) use only with virus circulating in the United States -- it is very likely the virus would have mutated, escaped the vaccine and killed millions in America.  Every single so-called expert knows damn well why we didn't do that with polio and how dangerous it is to attempt it.  Indeed where polio still circulates but money is scarce they use OPV only (which is sterilizing) and accept the risk of the rare but possible active case it can cause for this exact reason.

Again: This is not a "new idea"; it was in fact the only rational path of action and known decades ago, forming the very basis of our polio vaccination strategy.  This combination strategy was necessary for polio but not for measles, for example, as the measles vaccine is sterilizing.

ONLY A STERILIZING VACCINE IS SAFE TO USE ON A MASS POPULATION BASIS WHEN A PARTICULAR PATHOGEN IS CIRCULATING IN THE ENVIRONMENT.

THIS IS NOT THEORY -- IT IS DECADES-OLD KNOWN MEDICAL FACT.

In addition natural infection with Covid-19 is sterilizing.  Being infected and recovering conserves the nasal and respiratory mucosal response which is where the virus enters the body.  Natural infection also conveys both "N" (nucleocapsid) and "S" (spike) antibody knowledge and T-cell recognition but the "N" knowledge is much stronger as coronaviruses have evolved to evade the immune system with the "S" portion through millions of years.  This is why they can infect you in the first place.  The "S" portion undergoes mutation at a quite-rapid rate while the "N" portion is conserved.  It was thus expected that prior infection would lead to durable (years to decades) of resistance and indeed that's exactly what we have found thus far.  Indeed in a small study it was found that this recognition extended to the bone marrow in a large percentage of cases and in those people is likely to confer decades-long if not lifetime protection.  This is not true for "S" induced immunity as it wanes rapidly and, far worse that is where the mutation is taking place and thus where escape risk lies.

It was acceptable to issue EUAs for potentially non-sterilizing jabs to be used only by very high-risk individuals -- such as those in nursing homes -- with the understanding that they will fail to provide anywhere close to complete protection and might, over time potentiate worse outcomes.  But with actual informed consent and on a limited, not population-wide basis, that was defensible.  This, of course, leaves aside the adverse event risk -- which we also know is much higher in these jabs, by a factor of 100x or more, than we have ever tolerated in any mass-use shot before.

It was ridiculously and grossly negligent entering into the territory of depraved indifference to mass-vaccinate the population with non-sterilizing jabs.  We knew very early on that eradicating Covid-19 was impossible; there are animal reservoirs, specifically felines (of all sorts), ferrets and likely others (now believed to include deer.)  We have never eradicated rabies and never will for this reason; as long as there are animal reservoirs you cannot eradicate a virus as it always has a host and a means of transmission outside of human control.

As such there was never, and will never be, a safe means to use non-sterilizing vaccines against this virus or any other coronavirus and the more jabs we deliver and attempt to compel the use of the worse the problem will get.

Eventually we are very likely to get a mutation that entirely evades the jabs.  That mutation will be caused by those who are jabbed since they are the only ones placing such mutational pressure on the virus.  An unvaccinated person who gets infected places no such mutational pressure on the virus where a vaccinated person not only does they provide the exact pathway that virologists use to intentionally select for more-transmissible, virile or both mutations -- serial passage through cells that does not kill the host.

What is potentially worse is that there is a developing body of evidence that those who previously had Covid and then get vaccinated may destroy their "N" protein recognition by doing so, ruining their previous nearly-perfect immunity.  That we did not specifically prove that this did not happen before giving these shots to anyone with prior infection is outrageous.  While the data on this is quite thin at present that there is a higher breakthrough rate in persons with prior infection than those who were infected but did not get vaccinated is what the data currently shows, which strongly implies that vaccination after infection actually screws you.

The people who did all of this did so intentionally either by willful blindness or worse, with actual knowledge -- and the so-called "public health" authorities who continue to push this instead of banning it are intentionally doing so as well.  VanderCUNT is just one example of this insanity but hardly alone -- Johns Hopkins, Harvard, Mayo, Cleveland -- they all know this is true, never mind the researchers at Ft. Detrick, the CDC and NIH.

Until and unless we prove a vaccine against Covid (or anything else that is circulating) is sterilizing it cannot be safely used on a mass-population basis.  That's the beginning and end of the discussion.  There are no exceptions, ever, period.  This was not even attempted to be demonstrated in the summer and fall 2020 Covid vaccine trials as the time period was too short to do so.  We now know, factually that in fact there are zero sterilizing and effective options among the vaccines in use -- whether here in the US or otherwise.

The only means to combat a pathogen absent sterilizing vaccination is to hit infections early and hard with whatever you have for the purpose of reducing viral load so as to produce durable, sterilizing immunity via infection.  If you reduce viral load you reduce both the risk of pathology seriously injuring or killing the infected person and also reduce the forward transmission rate, Rt, of said virus. 

Only sterilizing immunity cuts off mutation and exerting mutational pressure via non-sterilizing vaccines not only promotes mutation by removing the signal an infected person has to self-isolate and reduce transmission risk (since you don't feel ill) it nudges the virus toward codons that will escape the protection in whole or part.

In small groups of particularly high risk a non-sterilizing vaccine may be worth it but any use of one raises the risk of mutational escape and thus while attempting to protect that small group you may screw others.  Attempting to accurately determine who "deserves" to get protected while someone else gets screwed is a discussion that damn well ought to take place out in public as it is the public at large that is the recipient of the screwing if it occurs!

There remains a risk that drug resistance may arise which is why multi-drug regimes are important.  As an example HCQ+Ivermectin which was formally registered as a trial and then never actually run, is (among other options) one such potential approach.

When it comes to respiratory viruses as was the case with polio you need immunity via whatever source to take hold at the point of both entry and emission by an infected person.  This is why OPV worked on a sterilizing basis for polio where IPV did not.  IPV was injected; OPV was consumed.  As a result OPV produced mucosal immunity in the gut and thus prevented both colonization and forward transmission.  IPV, on the other hand, prevented symptomatic disease in the person immunized but did not express sufficiently in the gut mucosa to prevent infection, shedding and transmission.

THE SAME APPLIES HERE WITH THE COVID JABS AND FOR THIS REASON THEY ARE AND ALWAYS WILL BE DANGEROUS, PROMOTING MUTATION AND ULTIMATELY VIRAL ESCAPE.

If you get Covid and beat it since the point of entry is your respiratory mucosa you have strong and broad resistance focused there.  That's sterilizing in more than 9 out of 10 persons and far more-durable than jab-based immunity as well.  That is what the data tells us. 

It is wildly superior to a non-sterilizing vaccine because you are not only very unlikely to get the virus again you are also nearly-certain to be unable to infect anyone else if you do.  This and only this is what cuts off mutational pressure.

It's too late now; we're stuck with the stupid, particularly all the screaming harpies who went out and got jabbed despite being at very low risk of serious outcomes themselves, turning themselves into literal gain-of-function labs for the virus.  If you took the jab, in short, unless you were at very high risk and thus it was justified on a personal mitigation basis you are, in fact, part of the body of individuals that are placing evolutionary pressure on the virus to evolve and ultimately evade the protection and screw not just others but you as well.

Those who are claiming "well, I got jabbed, I got infected, but it would have been much worse if I didn't get jabbed" are the worst of the psychotics.  First, the majority of Covid-19 infections are asymptomatic according to the CDC itself.  Indeed they claim at least six people get infected for each detected infection.  You may well have moved yourself from "I sneezed" to "I got pretty damned sick" by taking the shot.  You don't know.  But worse is that by taking the jab and then getting infected anyway you have now not just become a potential mutational factory you are one of the people causing what will ultimately become viral escape and the screwing of yourself and others because by definition if you got sick after vaccination the virus got into your system, it has now proved whatever occurred in you evaded the protection you had and then was emitted back out where others can catch it from you after that evasion took place.

You were either the mutational factory or an intermediate host that screws the next person you share the love with!

Not only did your protection against fail but, much worse, it's possible that said screwing will be enhanced by whatever residual antibody titer you may have since binding antibodies, if present (and which you intentionally put into your system) will still be present.  Even more-seriously you put the spike protein and thus the antibody response not in your nose and throat but in your blood vessels and other organs where they can cause the exact disease progression that occurs when Covid-19 kills people.  If you get a "break though" infection I hope you have your d-Dimer levels immediately checked because if not you may be a walking heart attack or stroke somewhere in the not-so-distant future with no other warning as a direct result of intentionally loading your body full of "protection" in the wrong place.

This, and only this, is why I will not consent to such a jab under any circumstances until and unless there is hard science showing that a sterilizing option exists.  That one, assuming the risk profile is reasonable, is one I might consider.  Said jab today does not exist anywhere in the United States and I'm unaware of any scientific work showing that any of the current jabs are sterilizing irrespective of where they are manufactured and sold.

Without sterilizing immunization against this disease the only sane approach is to attempt to interdict the progress of disease at first suspicion and evidence of infection instead.

I am capable of reading both history and scientific papers, I know I'm right, the CDC, NIH, VanderCunt, Mayo, Cleveland and Johns Hopkins also knew for decades that I'm right and they have either all turned what formerly were scientific organizations into politically-driven soy-boy pieces of worthless and even harmful crap or, much worse, they're deliberately lying.

If you were among the conned the only remaining question is what are you going to do with and to those who conned you?

Stay tuned for the next exciting episode of "You're fucked, fool."

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